ADVANCED DRUG DELIVERY SYSTEMS: NANOPARTICLE-BASED PLATFORMS FOR TARGETED THERAPY AND CONTROLLED RELEASE

Abstract

This study investigates the development and evaluation of nanoparticle-based drug delivery systems designed to enhance targeted therapy and controlled drug release, with a focus on cancer treatment. The synthesized nanoparticles exhibited optimal characteristics, including sizes ranging from 150 to 200 nm, which are ideal for enhanced tumor penetration and retention. The zeta potential values between -20 mV and -30 mV contributed to the stability and prolonged circulation time of the nanoparticles. Notably, the encapsulation efficiency was greater than 80%, ensuring sustained release and minimizing premature drug leakage.The drug delivery system reveals pH-dependent release features that demonstrate acidic pH (pH 5.5) achieves the highest drug release rate while reproducing conditions related to tumor environments to enhance targeted drug delivery for cancer treatment.  The most successful nanoparticle formulation named NP5 exhibited superior tumor growth suppression (80%) along with great cytotoxicity due to its IC50 value of 3.0 µg/mL. Effective anticancer action emerges from the studies while the targeted delivery effects become strengthened by surface functionalization which results in NP5 achieving both optimal cellular intake and noticeable tumor concentration.  The biodistribution studies revealed that NP5 delivered most of its content to tumors where it minimized distribution to non-target organs thus improving treatment results while reducing systemic adverse effects.  Our results point to an upcoming clinical use of nanoparticle-based systems which offer better cancer treatment through targeted delivery and controlled drugs.  The study enables scientists to make nanoparticle systems dedicated for treating various illnesses while directing drugs precisely and minimizing toxicities